Tirzepatide

What is it?

Tirzepatide is a dual GLP-1 and GIP receptor agonist originally developed for Type 2 diabetes and now widely used for weight loss and metabolic support. It works by reducing appetite, increasing fullness, and improving insulin sensitivity.

Key Benefits

• Strong appetite suppression and weight loss support

• Helps improve blood sugar control and insulin sensitivity

• Supports fat metabolism and body recomposition

• May reduce cravings and improve satiety

• Often produces greater weight loss than Semaglutide

Possible Side Effects

Common

• Nausea

• Constipation or diarrhea

• Fatigue

• Indigestion

• Abdominal discomfort

• Sulfur burps

• Hair loss

Rare but Serious

• Pancreatitis

• Gastroparesis

• Gallbladder disease

• Kidney complications from dehydration

• Thyroid tumor risk

• Hypoglycemia when combined with insulin

Important Warnings

Use caution with:

• Insulin or diabetes medications

• Alcohol

• Appetite suppressants

• Stimulants

• Large greasy meals

Avoid stacking with other GLP-1 peptides unless medically supervised.

Always disclose Tirzepatide use before surgery or anesthesia.

Contraindications

Do not use if:

• Pregnant or breastfeeding

• Personal/family history of medullary thyroid cancer

• MEN 2 syndrome

• Type 1 diabetes

• Severe GI disease

• Allergic to Tirzepatide

Tirzepatide Dosing Protocols

General Guidelines

• Subcutaneous injection

• Dose once weekly

• Use the same day weekly

• Stay on each dose at least 4 weeks before increasing

• Can be taken with or without food

Starting Dose

New to GLP-1 Medications

• 2.5mg weekly

Previous GLP-1 Users

• 5mg weekly

15mg Vial

Reconstitution

Mix:

• 10mg vial + 1.5mL (150 units) BAC water

Dose Reference

• 25 units = 2.5mg

• 50 units = 5mg

• 75 units = 7.5mg

• 100 units = 10mg

30mg Vial

Reconstitution

Mix:

• 30mg vial + 3mL (300 units) BAC water

Dose Reference

• 25 units = 2.5mg

• 50 units = 5mg

• 75 units = 7.5mg

• 100 units = 10mg

• 125 units = 12.5mg

• 150 units = 15mg

60mg Vial

Reconstitution

Mix:

• 60mg vial + 2.5mL (250 units) BAC water

Dose Reference

• 10 units = 2.5mg

• 21 units = 5mg

• 31 units = 7.5mg

• 42 units = 10mg

• 52 units = 12.5mg

• 62 units = 15mg

Suggested Stacks

• AOD-9604 for fat metabolism support

• Tesamorelin for visceral fat reduction

• Semax or Selank for mood and focus support

• NAD+ or MOTS-C for energy and metabolic support

• BPC-157 for GI support and recovery

• CJC-1295 + Ipamorelin for muscle preservation during weight loss