Retatrutide

What is it?

Retatrutide is a triple-agonist metabolic peptide that targets GLP-1, GIP, and glucagon receptors. It is designed for advanced weight loss, appetite suppression, glucose control, and metabolic support.

Key Benefits

• Powerful appetite suppression and fat loss support

• Supports glucose control and insulin sensitivity

• Increases energy expenditure and fat metabolism

• May improve body composition and visceral fat reduction

• Supports metabolic and cardiovascular health

How It Works

Retatrutide activates:

• GLP-1 receptors, appetite suppression and slowed gastric emptying

• GIP receptors, insulin sensitivity and metabolic support

• Glucagon receptors, increased fat burning and energy expenditure

Possible Side Effects

Common

• Nausea

• Constipation or diarrhea

• Headache

• Indigestion

• Abdominal discomfort

• Dehydration

Rare but Serious

• Gallbladder issues

• Pancreatitis

• Gastroparesis

• Kidney strain from dehydration

• Severe allergic reactions

Side Effect Management

• Stay hydrated

• Avoid greasy foods

• Eat smaller meals

• Increase fiber intake if constipated

• Night dosing may improve tolerability

Important Warnings

Use caution if you have:

• History of pancreatitis

• Gallbladder disease

• Severe GI disorders

Do not use if:

• Pregnant or breastfeeding

• Chronic kidney disease

• Advanced liver disease

• Severe GI disorders

• Personal/family history of thyroid cancer

Avoid stacking with other GLP-1 agonists unless medically supervised.

Retatrutide Dosing Protocols

General Guidelines

• Subcutaneous injection

• Dose once weekly

• Stay on each dose at least 4 weeks

• Best taken with a light meal

• Avoid alcohol or very large meals around dosing

Cycle Recommendation

• Common cycle: 16 weeks

• Washout: minimum 8 weeks

Starting Dose

New to GLP-1s

• 2mg weekly

Previous GLP-1 Users

• 4mg weekly

10mg Vial

Reconstitution

Mix:

• 10mg vial + 1mL (100 units) BAC water

Dose Reference

• 20 units = 2mg

• 40 units = 4mg

• 60 units = 6mg

• 80 units = 8mg

• 100 units = 10mg

60mg Vial

Reconstitution

Mix:

• 60mg vial + 2.5mL (250 units) BAC water

Dose Reference

• 8 units = 2mg

• 17 units = 4mg

• 25 units = 6mg

• 33 units = 8mg

• 42 units = 10mg

• 50 units = 12mg

Suggested Stacks

• AOD-9604 for fat metabolism support

• BPC-157 + TB-500 for recovery support

• GHK-Cu for skin tightening and collagen support

• Semax or Selank for mood and focus support

• Glutathione for antioxidant and liver support

• Lipo-C for energy and fat metabolism