Semaglutide

What is it?

Semaglutide is a GLP-1 receptor agonist originally developed for Type 2 diabetes and now widely used for weight loss and appetite control. It works by slowing gastric emptying, increasing fullness, and reducing appetite.

Key Benefits

Powerful appetite suppression and weight loss support
Helps improve blood sugar control
May reduce food cravings and binge eating
Supports cardiovascular and metabolic health
May reduce inflammation and improve body composition

Possible Side Effects

Common

Nausea
Constipation or diarrhea
Bloating or sulfur burps
Fatigue
Headache
Heartburn

Rare but Serious

Pancreatitis
Gallbladder disease
Gastroparesis
Kidney complications
Thyroid tumors/cancer risk
Mood changes or suicidal thoughts

Contraindications

Do not use if:

Pregnant or breastfeeding
Personal/family history of medullary thyroid cancer
MEN 2 syndrome
History of pancreatitis or gallbladder disease
Allergic to GLP-1 medications

Use caution if you have:

Severe GI disorders
Diabetic retinopathy
Kidney disease
Upcoming surgery/anesthesia

Semaglutide Dosing Protocols

General Guidelines

Subcutaneous injection
Dose once weekly
Use the same day weekly
Stay on each dose at least 4 weeks before increasing
Bedtime dosing may reduce side effects

5mg Vial

Reconstitution

Mix:

5mg vial + 1mL (100 units) BAC water

Dose Reference

5 units = 0.25mg
10 units = 0.5mg
15 units = 0.75mg
20 units = 1mg
25 units = 1.25mg
30 units = 1.5mg
35 units = 1.75mg
40 units = 2mg
45 units = 2.25mg
50 units = 2.5mg

10mg Vial

Reconstitution

Mix:

10mg vial + 2mL (200 units) BAC water

Dose Reference

Same unit conversion as 5mg vial:

5 units = 0.25mg
50 units = 2.5mg

Suggested Stacks

AOD-9604 for fat metabolism support
L-Carnitine for energy and endurance
NAD+ for metabolic and mitochondrial support
BPC-157 + TB-500 for recovery and gut support
CJC-1295 + Ipamorelin for muscle preservation
Glutathione for liver and antioxidant support

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